Preferred Label : Allogeneic Calibrated Release IL-15-expressing Logic-Gated Gene Circuit Anti-CD33/FLT3
CAR-NK Cells SENTI-202;
NCIt synonyms : Allogeneic Logic Gated CAR NK Cells SENTI-202; Allogeneic CD33 OR FLT3 NOT EMCN Logic Gated Gene Circuit CAR NK Cells SENTI-202; Allogeneic Calibrated Release IL-15-expressing Bivalent CD33/FLT3 Logic Gated Gene
Circuit CAR-NK Cells SENTI-202; CD33/FLT3 CAR-crIL15-expressing NK Cells SENTI-202; Allogeneic crIL15-expressing Logic-Gated Gene Circuit Anti-CD33/FLT3 CAR-NK Cells
SENTI-202;
NCIt definition : A preparation of off-the-shelf (OTS) natural killer (NK) cells engineered to express
three chimeric proteins: 1) a bivalent activating chimeric antigen receptor (aCAR),
controlled by OR logic gated gene circuit, specific for the tumor-associated antigens
(TAAs) cluster of differentiation 33 (CD33) and FLT3 tyrosine kinase receptor (Fms-like
tyrosine kinase 3; FLT3; FLT-3; CD135; fetal liver kinase-2; FLK2) (CD33 OR FLT3 (OR
GATE) aCAR), 2) an inhibitory CAR (iCAR) recognizing endomucin (EMCN) and controlled
by NOT logic gate (NOT EMCN (NOT GATE) iCAR), and 3) a calibrated release interleukin
15 (IL-15) (crIL15), with potential immunostimulating and antineoplastic activities.
Upon administration, the allogeneic crIL-15-expressing logic-gated gene circuit anti-CD33/FLT3
CAR-NK cells SENTI-202 targets and binds to CD33 and/or FLT3 expressed on the surface
of tumor cells, such as primary acute myeloid leukemia (AML) blasts and leukemic stem
cells (LSCs). This induces selective toxicity in tumor cells expressing CD33 and/or
FLT3. To protect CD33/FLT3-expressing healthy hematopoietic stem cells (HSCs) from
potential aCAR-mediated on-target/off-tumor toxicity, the iCAR recognizes and binds
to the healthy cell surface protein EMCN, which is selectively expressed on healthy
HSCs but absent on tumor cells. The crIL-15 allows for activation of the IL-15 receptor
pathway, which increases the persistence, activation and killing activity of SENTI-202
and other immune cells. CD33 and FLT3 are expressed on healthy HSCs and on a variety
of cancer cells.;
Molecule name : SENTI 202; SENTI-202;
NCI Metathesaurus CUI : CL1928927;
Origin ID : C206380;
concept_is_in_subset
- has_target
