Preferred Label : Denfivontinib Hydrochloride;
NCIt synonyms : G-749 HCl Salt; FLT3 Tyrosine Kinase Inhibitor SKI-G-801; FLT3 Kinase Inhibitor SKI-G-801; G-749 Hydrochloride; FLT3 Inhibitor SKI-G-801;
NCIt definition : The hydrochloride salt form of denfivontinib, an orally bioavailable inhibitor of
both wild type and mutant forms of FMS-like tyrosine kinase 3 (FLT3; CD135; STK1;
FLK2), with potential antineoplastic activity. Upon administration, denfivontinib
binds to and inhibits the activity of FLT3, including FLT3-ITD (internal tandem duplications),
FLT3-D835Y as well as other mutants. This inhibits uncontrolled FLT3 signaling and
results in the inhibition of proliferation in tumor cells overexpressing FLT3. FLT3,
a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B
lineage neoplasms and in acute myeloid leukemias, and plays a key role in tumor cell
proliferation. In addition, denfivontinib also inhibits, to a lesser degree, the receptor
tyrosine kinases AXL (UFO), Mer, Ret, vascular endothelial growth factor receptor
1 (VEGFR1), Fms, fibroblast growth factor receptors (FGFR) 1 and 3, and the serine/threonine
kinases Aurora B and C.;
UNII : 01ZQ25VJAL;
CAS number : 1457983-33-3;
Molecule name : G-801; SKI-G-801;
NCI Metathesaurus CUI : CL556252;
Origin ID : C155773;
UMLS CUI : C5783370;
Semantic type(s)
- concept_is_in_subset
- has_target
