Preferred Label : FLT3 Agonist-Fc Fusion Protein GS-3583;
NCIt synonyms : Flt3R Agonist GS-3583; FLT3 Agonist Fc Fusion Protein GS-3583;
NCIt definition : A fusion protein composed of fms-related tyrosine kinase 3 ligand (FLT3L) and agonist
fused to an immunoglobulin (Ig) fragment crystallizable region (Fc region), with potential
immunostimulating activity. Upon administration of the FLT3 agonist-Fc fusion protein
GS-3583, the FLT3 agonist moiety specifically targets, binds to, and activates FLT3
and, synergistically with other growth factors, stimulates the proliferation and mobilization
of bone marrow precursor cells, including CD34 cells, and dendritic cells (DCs).
FLT3 agonist-Fc fusion protein GS-3583 has a longer serum half-life compared with
soluble FLT3L.;
Molecule name : GS 3583; GS-3583;
NCI Metathesaurus CUI : CL1662424;
Origin ID : C179655;
UMLS CUI : C5555846;
Semantic type(s)
- concept_is_in_subset
- has_target
