Preferred Label : Anti-FLT3 Antibody-drug Conjugate AGS62P1;
NCIt synonyms : ADC AGS62P1;
NCIt related terms : AGS62P1;
NCIt definition : An antibody-drug conjugate (ADC) composed of a human monoclonal antibody directed
against the extracellular domain of receptor-type tyrosine-protein kinase FLT3 (FLT-3;
FMS-like tyrosine kinase 3; CD135; fetal-liver kinase 2; FLK2) and conjugated, via
an oxime linker and the site-directed non-natural amino acid linker para-acetyl-phenylalanine
(pAcF), to a microtubule-disrupting cytotoxic agent, with potential antineoplastic
activity. Upon administration of ADC AGS62P1, the antibody moiety targets and binds
to FLT3. Upon antibody/antigen binding and internalization, the microtubule-targeting
agent binds to and inhibits tubulin polymerization, which results in G2/M phase arrest
and tumor cell apoptosis. The site-specific conjugation of the cytotoxic agent to
the antibody, through pAcF, improves the biophysical properties of AGS62P1, increases
payload distribution and stability, and optimizes its efficacy. FLT3, a class III
tyrosine kinase receptor, is overexpressed or mutated in most B lineage, acute lymphoblastic
leukemias and acute myeloid leukemias.;
UNII : 37I4D4Q7S2;
Molecule name : AGS62P1;
NCI Metathesaurus CUI : CL513016;
Origin ID : C129937;
UMLS CUI : C4329324;
Semantic type(s)
- concept_is_in_subset
- has_target
