Preferred Label : FLT3 Inhibitor FF-10101 Succinate;
NCIt synonyms : FF-10101 Succinate; FF10101 Succinate;
NCIt definition : The succinate salt form of FF-10101, a FMS-like tyrosine kinase 3 (FLT3; CD135; STK1;
FLK2) inhibitor, with potential antineoplastic activity. Upon administration of FLT3
inhibitor FF-10101 succinate (FF-10101-01), FF-10101 irreversibly binds to and inhibits
the activity of FLT3. This inhibits the proliferation of FLT3-expressing cancer cells.
FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most
B lineage neoplasms and in acute myeloid leukemias.;
Molecule name : FF-10101-01;
NCI Metathesaurus CUI : CL524957;
Origin ID : C137988;
UMLS CUI : C4527305;
Semantic type(s)
- concept_is_in_subset
- has_target
