Autologous Anti-FLT3 CAR T Cells TAA05

Preferred Label : Autologous Anti-FLT3 CAR T Cells TAA05;

NCIt synonyms : Autologous FLT3-targeting CAR-T Cells TAA05; Autologous Anti-FMS-like Tyrosine Kinase 3 CAR T-cells TAA05;

NCIt definition : A preparation of autologous T-lymphocytes genetically engineered with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-FLT3 CAR T cells TAA05 target and bind to tumor cells expressing FLT3, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of FLT3-expressing tumor cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias (AMLs).;

Molecule name : TAA-05; TAA 05;

NCI Metathesaurus CUI : CL1771900;

Details

Origin ID

C183535;

UMLS CUI

C5666913;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Receptor-Type Tyrosine-Protein Kinase FLT3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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