Preferred Label : Flt3/MerTK Inhibitor MRX-2843;
NCIt synonyms : MRX 2843;
NCIt related terms : MRX-2843;
NCIt definition : An orally bioavailable inhibitor of two receptor tyrosine kinases (RTKs), FMS-like
tyrosine kinase-3 (Flt3; CD135; fetal liver kinase-2; Flk2) and tyrosine-protein kinase
Mer (MerTK; proto-oncogene c-Mer; Mer), with potential antineoplastic activity. Upon
administration, MRX-2843 targets and binds to both Flt3 and MerTK. This prevents ligand-dependent
phosphorylation and activation of Flt3 and MerTK, which inhibits the activation of
their downstream signaling pathways. This induces apoptosis and inhibits proliferation
of Flt3- and/or MerTK-overexpressing tumor cells. Flt3 and MerTK, are overexpressed
in certain tumor cell types and play key roles in tumor cell proliferation and survival.;
UNII : 2MT30EHI63;
CAS number : 1429882-07-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1429882-07-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : MRX-2843; UNC-2371A;
NCI Metathesaurus CUI : CL553239;
Origin ID : C151407;
UMLS CUI : C4726538;
Semantic type(s)
- concept_is_in_subset
- has_target
