NCIt definition : An orally bioavailable inhibitor of both the serine/threonine protein kinase Aurora
kinase and FMS-related tyrosine kinase 3 (FLT3; STK1; CD135; FLK2), with potential
antineoplastic activity. Upon oral administration, mobinitinib specifically binds
to and inhibits Aurora kinase and FLT3, which interferes with the activation of Aurora
kinase- and FLT3-mediated signal transduction pathways. This may result in the disruption
of the assembly of the mitotic spindle apparatus, the disruption of chromosome segregation
and the inhibition of cell proliferation in tumor cells that overexpress Aurora kinase
and/or FLT3. Aurora kinase plays essential roles in mitotic checkpoint control during
mitosis. Aurora kinase and FLT3 are overexpressed in a variety of cancers and play
key roles in tumor cell proliferation.;
UNII : ZE94SP78UG;
CAS number : 1402709-93-6;
Molecule name : EP-0042; EP 0042; CCT-241736; CCT 241736;
Semantic type(s)