NCIt definition : A human, Fc-optimized, immunoglobulin G1 (IgG1) monoclonal antibody directed against
the FLT3 tyrosine kinase receptor (CD135), with potential antineoplastic activity.
Upon binding to FLT3, anti-FLT3 monoclonal antibody 4G8-SDIEM blocks FLT3 ligand binding
to FLT3 and subsequent phosphorylation of FLT3, which may result in the inhibition
of FLT3-mediated signal transduction pathways. In addition, this agent may stimulate
an anti-FLT3 antibody-dependent cell-mediated cytotoxicity (ADCC) against FLT3-expressing
tumor cells, which may lead to the inhibition of cellular proliferation and decreased
survival in FLT3-expressing cells. FLT3 (FLK2), a class III tyrosine kinase receptor,
is overexpressed or mutated in most B lineage and acute myeloid leukemias.;
Semantic type(s)