LIS1 Pathway - CISMeF

Preferred Label : LIS1 Pathway;

NCIt related terms : Lissencephaly gene (LIS1) in neuronal migration and development;

Alternative definition : BIOCARTA: LIS1 can bind to MT bundles; however, phospho-LIS1 binding to MT bundles is mediated through the distal zinc finger motif of CLIP-170. When the distal zinc finger motif of CLIP-170 is mutated, the phospho-LIS1 isoform can no longer bind to MT bundles. This can also explain why p150/dynactin is not recruited to the MT bundles. CLIP-170 targets the dynein/dynactin complex to the MT, using phopho-LIS1 as an adapter; the motor complex, being in the proximity of the MT, associates with it. The initial static link to the MT provided by CLIP-170 is released by its hyperphosphorylation and the retrograde dynein/dynactin-dependent movement of the cargo (endocytic vesicle, kinetochore, etc.) takes place. Doublecortin (DCX) is placed close to the LIS1 pathway based on its interaction with LIS1 and its role in microtubule dynamics. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_Lis1Pathway;

Details

Origin ID

C39140;

UMLS CUI

C1517693;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Casein Kinase II Subunit Alpha [NCIt concept]
- Cyclin-Dependent Kinase 5 [NCIt concept]
- Cyclin-Dependent Kinase 5 Activator 1 [NCIt concept]
- Low-Density Lipoprotein Receptor-Related Protein 8 [NCIt concept]
- Platelet-Activating Factor Acetylhydrolase IB Subunit Alpha [NCIt concept]
- Reelin [NCIt concept]
- Tyrosine-Protein Kinase ABL1 [NCIt concept]
pathway_has_gene_element
- ABL1 wt Allele [NCIt concept]
- CDK5 wt Allele [NCIt concept]
- CDK5R1 wt Allele [NCIt concept]
- CSNK2A1 wt Allele [NCIt concept]
- LRP8 wt Allele [NCIt concept]
- PAFAH1B1 wt Allele [NCIt concept]
- RELN wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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