Platelet-Activating Factor Acetylhydrolase IB Subunit Alpha

Preferred Label : Platelet-Activating Factor Acetylhydrolase IB Subunit Alpha;

NCIt synonyms : PAF Acetylhydrolase 45 kDa Subunit; Lissencephaly-1 Protein; PAF-AH 45 kDa Subunit; PAFAH Alpha; LIS-1; PAF-AH Alpha;

NCIt definition : Platelet-activating factor acetylhydrolase IB subunit alpha (410 aa, 47 kDa) is encoded by the human PAFAH1B1 gene. This protein is involved in neuronal migration.;

NCIt note : Platelet-activating factor acetylhydrolase IB subunit alpha is a non-enzymatic subunit for the platelet-activating factor acetylhydrolase IB but is required for Rho GTPase activation and actin polymerization to promote neuronal migration in response to the calcium influx induced by NMDA receptor activity. (UniProt);

Details

Origin ID

C75887;

UMLS CUI

C2698835;

OMIM relation
- Platelet-activating factor acetylhydrolase, isoform 1b, alpha subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
gene_encodes_gene_product
- PAFAH1B1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- LIS1 Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Migration Process [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients