Low-Density Lipoprotein Receptor-Related Protein 8

Preferred Label : Low-Density Lipoprotein Receptor-Related Protein 8;

NCIt synonyms : ApoER2; Apolipoprotein E Receptor 2; LRP-8;

NCIt definition : Low-density lipoprotein receptor-related protein 8 (963 aa, 106 kDa) is encoded by the human LRP8 gene. This protein plays a role in lipid metabolism, ligand recognition and signal transduction.;

NCIt note : Low-density lipoprotein receptor-related protein 8 may be involved in aggravated thrombosis associated with antiphospholipid syndrome. (J Clin Invest. 2011; 121: 120-131);

Details

Origin ID

C95251;

UMLS CUI

C1568173;

Currated CISMeF NLP mapping
- low density lipoprotein receptor-related protein 8 [MeSH concept]
- low density lipoprotein receptor-related protein 8 [MeSH Supplementary Concept]
OMIM relation
- Low density lipoprotein receptor-related protein 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- LRP8 protein, human [MeSH concept]
gene_encodes_gene_product
- LRP8 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Caveola [NCIt concept]
gene_product_has_chemical_classification
- Cell Surface Receptor [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- LIS1 Pathway [NCIt concept]
- Lissencephaly-1 Gene in Neuronal Migration and Development [NCIt concept]
- Reelin Signaling Pathway BioCarta [NCIt concept]
- Reelin Signaling Pathway PID [NCIt concept]
gene_product_malfunction_associated_with_disease
- Myocardial Infarction [NCIt concept]
gene_product_plays_role_in_biological_process
- Endocytotic Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Lipid Metabolic Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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