DNA Replication Licensing Factor MCM2

Preferred Label : DNA Replication Licensing Factor MCM2;

NCIt synonyms : D3S3194; Minichromosome Maintenance Protein 2; Minichromosome Maintenance Protein 2 Homolog; Cyclin-Like 1; Cell Devision Cycle-Like 1; cdc19; MGC10606; MCM2; CDCL1; CCNL1; BM28; Mitotin; Nuclear Protein BM28; MCM2 Protein; Minichromosome Maintenance Protein-2;

NCIt definition : DNA replication licensing factor MCM2 (904 aa, 102 kDa) is encoded by the human MCM2 gene. This protein plays a role in cell cycle regulation.;

NCIt note : MCM4, MCM6, and MCM7 form a stable complex with which MCM2 is loosely associated. The presence of MCM2 disturbs the assembly of MCM4, MCM6, and MCM7 proteins to inhibit the DNA helicase activity. Through specific binding of MCM2 with histone H3, the complex binds chromatin. Phosphorylation of MCM2 and MCM3 in the MCM complex by the CDC7L1 kinase complex converts the inactive MCM complex into an active helicase.;

Details

Origin ID

C28642;

UMLS CUI

C1437703;

Automatic exact mappings (from CISMeF team)
- Cyclin l1 [OMIM gene]
- Minichromosome maintenance complex component 2 [OMIM gene]
- Minichromosome maintenance complex component 7 [OMIM gene]
- minichromosome maintenance complex component 2 [MeSH Descriptor]
- minichromosome maintenance complex component 2 [ORDO Gene]
- minichromosome maintenance complex component 2 [HGNC gene]
OMIM relation
- Minichromosome maintenance complex component 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MCM2 protein, human [MeSH concept]
- MCM2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- Licensing Factor Gene [NCIt concept]
- MCM2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- MCM Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cell Division Process [NCIt concept]
- Replication Initiation [NCIt concept]
- Replication Licensing [NCIt concept]

Keyword's position in hierarchy(ies) :

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