Preferred Label : Transcription Factor Dp-2;
NCIt synonyms : E2F Dimerization Partner 2; DRTF1; TFDP2; Transcription Factor-DP2;
NCIt definition : Transcription factor Dp-2 (446 aa, 49 kDa) is encoded by the human TFDP2 gene. This
protein is involved in transcriptional regulation and cell cycle progression.;
NCIt note : Expressed in heart, skeletal muscle, placenta, kidney, brain, lung, and liver, human
TFDP2 Gene (E2F/DP Family) encodes alternative isoforms alpha (446-aa, 49-kDa), beta
(369-aa, 43-kDa), gamma (370-aa), and delta (385-aa, 48-kDa) of phosphorylated nuclear
Transcription Factor Dp-2, which in a heterodimeric complex with E2F family members
regulates genes required for G1/S cell-cycle progression, S-phase progression, cell
cycle regulation, DNA replication, or apoptosis. Interaction of DP/E2F with hypophosphorylated
RB1, P107, and P130 inhibits the E2F transactivation domain. In mid-to-late G1, phosphorylated
RB detaches from DP/E2F rendering E2F transcriptionally active. Viral oncoproteins
E1A, T-antigen, and HPV E7 can sequester RB protein, releasing active DP/E2F complex.; Transcription factor Dp-1 binds DNA cooperatively with E2F family members through
the E2 recognition site, 5'-TTTC[CG]CGC-3'. (UniProt);
Origin ID : C30093;
UMLS CUI : C0528328;
OMIM relation
- Semantic type(s)
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_is_element_in_pathway
- gene_product_is_physical_part_of
- gene_product_plays_role_in_biological_process
