Protein DBF4 homolog A

Preferred Label : Protein DBF4 homolog A;

NCIt synonyms : Dumbbell Former 4 Homolog; DBF4 Homolog; Activator of S Phase Kinase; ASK; Chiffon Homolog A; DBF4-Type Zinc Finger-Containing Protein 1;

NCIt definition : Protein DBF4 homolog A (674 aa, 77 kDa) is encoded by the human DBF4 gene. This protein plays a role in DNA replication and cell proliferation and is required for the progression of S phase during mitosis.;

NCIt note : Encoded by growth factor and E2F-regulated widely expressed human ASK Gene, 77-kD nuclear Activator of S Phase Kinase (dup) is a cyclin-like regulatory subunit of CDC7L1 kinase involved in G1/S transition. ASK mRNA and protein are low in G1, peak in S phase, and reduce in G2/M; ASK is extensively phosphorylated during S phase. Containing a bipartite NLS, conserved motifs N (N-terminus) and C (central region), and 2 PEST sequences, ASK appears essential for entry into S phase. Motif C is essential for CDC7L1 catalytic subunit interaction with ASK, a major activator of CDC7L1 kinase activity on MCM2.; The G1/S transition in eukaryotic cells is strictly regulated so that DNA replication occurs only once during S phase. The CDC7L1 kinase complex may trigger S phase by directly activating the replication initiation complexes assembled at the origins. Phosphorylation of MCM2 and MCM3 in the MCM complex by the CDC7L1 kinase complex converts the inactive MCM complex into an active helicase. Activator of S Phase Kinase, encoded by the ASK gene, is a cyclin-like regulatory subunit of the CDC7L1 kinase complex. This protein is the major activator of CDC7L1. ASK plays a pivotal role in the G1/S transition in mammalian cells and its function is essential for entry into S phase. ASK interacts with CDC7L1 and stimulates the kinase activity of CDC7L1. CDC7L1-dependent kinase activity reflects the ASK protein level, significantly increasing in cells in S phase, and ASK protein is extensively phosphorylated during S phase, presumably by CDC7L1.;

Details

Origin ID

C28671;

UMLS CUI

C1172410;

OMIM relation
- Dbf4 zinc finger [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- DBF4 protein, human [MeSH Supplementary Concept]
- DBF4 protein, human [MeSH concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- DBF4 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
gene_product_is_physical_part_of
- CDC7L1 Kinase Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- G1 to S Transition Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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