Activator of S Phase Kinase

Preferred Label : Activator of S Phase Kinase;

Obsolete resource : true;

NCIt synonyms : Dumbbell Former 4 Homolog; ASK; DBF4 Homolog;

NCIt definition : Encoded by growth factor and E2F-regulated widely expressed human ASK Gene, 77-kD nuclear Activator of S Phase Kinase (dup) is a cyclin-like regulatory subunit of CDC7L1 kinase involved in G1/S transition. ASK mRNA and protein are low in G1, peak in S phase, and reduce in G2/M; ASK is extensively phosphorylated during S phase. Containing a bipartite NLS, conserved motifs N (N-terminus) and C (central region), and 2 PEST sequences, ASK appears essential for entry into S phase. Motif C is essential for CDC7L1 catalytic subunit interaction with ASK, a major activator of CDC7L1 kinase activity on MCM2.;

NCIt note : Merged with Activator of S Phase Kinase;

Concept status : Retired_Concept;

Details

Origin ID

C28703;

OMIM relation
- Dbf4 zinc finger [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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