DNA Replication Licensing Factor MCM6

Preferred Label : DNA Replication Licensing Factor MCM6;

NCIt synonyms : Minichromosome Maintenance Protein 6; MCM6; MIS5; P105MCM; EC 3.6.4.12; DNA Replication Licensing Factor-MCM6;

NCIt definition : DNA replication licensing factor MCM6 (821 aa, 93 kDa) is encoded by the human MCM6 gene. This protein is involved in DNA replication.;

NCIt note : MCM6 is rapidly induced at G1/S by growth factor stimulation; protein level peaks at G1/S. A stable MCM2/4/6/7 complex exhibits DNA unwinding ATPase/DNA helicase activity involved in replication initiation. MCM2/4/6/7 phosphorylation by CDC2 kinase reduces helicase activity. Hexameric MCM2-7 complex is a key element of the pre-replication complex and may be involved in formation of replication forks and in recruitment of replication factors.;

Details

Origin ID

C33911;

UMLS CUI

C1333240;

Automatic exact mappings (from CISMeF team)
- Minichromosome maintenance complex component 6 [OMIM gene]
- Minichromosome maintenance complex component 6 [ORDO Gene]
- minichromosome maintenance complex component 6 [MeSH Descriptor]
- minichromosome maintenance complex component 6 [ORDO Gene]
OMIM relation
- Minichromosome maintenance complex component 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MCM6 protein, human [MeSH concept]
- MCM6 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Helicase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Licensing Factor Gene [NCIt concept]
- MCM6 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- MCM Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Maintenance Process [NCIt concept]
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleic Acid Binding [NCIt concept]
- Replication Initiation [NCIt concept]
- Replication Licensing [NCIt concept]

Keyword's position in hierarchy(ies) :

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