Transcription Factor E2F4

Preferred Label : Transcription Factor E2F4;

NCIt synonyms : E2F Transcription Factor 4; p107/p130-Binding Protein; E2F-4;

NCIt definition : Transcription factor E2F4 (413 aa, 44 kDa) is encoded by the human E2F4 gene. This protein plays a role in the modulation of tumor suppressor-dependent gene expression.;

NCIt note : Transcription factor E2F4 binds cooperatively with DP-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. (UniProt);

Details

Origin ID

C125266;

UMLS CUI

C1529670;

Automatic exact mappings (from CISMeF team)
- E2F transcription factor 4 [HGNC gene]
- E2F4 transcription factor [MeSH concept]
- E2f transcription factor 4 [OMIM gene]
- e2f4 transcription factor [MeSH Descriptor]
OMIM relation
- E2f transcription factor 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- E2F4 protein, human [MeSH Supplementary Concept]
- E2F4 protein, human [MeSH concept]
gene_encodes_gene_product
- E2F4 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- E2F Transcription Factor Family [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- Macrophage Differentiation Pathway [NCIt concept]
- Regulation of Retinoblastoma Protein Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_product_is_physical_part_of
- DREAM Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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