Securin - CISMeF

Preferred Label : Securin;

NCIt synonyms : Pituitary Tumor-Transforming Gene 1 Protein; EAP1; PTTG1 Gene Product; hPTTG; ESP1-Associated Protein 1; Tumor-Transforming Protein 1; PTTG1;

NCIt definition : Securin (202 aa, 22 kDa) is encoded by the human PTTG1 gene. This protein plays a role in chromosomal maintenance.;

NCIt note : Securin is an anaphase-promoting complex substrate, involved in regulation of chromatid separation. Has effects on cell cycle regulation, cellular proliferation, and cellular transformation. It is a cytosolic, proline-rich protein with several SH3 sites and N-terminal basic and C-terminal acidic domains.;

Details

Origin ID

C18581;

UMLS CUI

C1309143;

Automatic exact mappings (from CISMeF team)
- Interferon regulatory factor 2-binding protein like [OMIM gene]
- PTTG1 regulator of sister chromatid separation, securin [HGNC gene]
- Pttg1 regulator of sister chromatid separation, securin [OMIM gene]
- interferon regulatory factor 2 binding protein like [ORDO Gene]
- securin [MeSH Descriptor]
- securin [MeSH concept]
- securine A [MeSH Supplementary Concept]
- securine A [MeSH concept]
OMIM relation
- Pttg1 regulator of sister chromatid separation, securin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- pituitary tumor-transforming protein 1, human [MeSH Supplementary Concept]
- pituitary tumor-transforming protein 1, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- PTTG1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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