securin - CISMeF

Preferred Label : securin;

MeSH definition : Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.;

MeSH synonym : pituitary Tumor-Transforming proteins; pituitary tumor transforming proteins; PTTG protein; pituitary Tumor-Transforming gene protein;

Is substance : O;

Details

Origin ID

D064249;

UMLS CUI

C3853746;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Pttg1 regulator of sister chromatid separation, securin [OMIM gene]
- Securin [NCIt concept]
Record concept(s)
- securin [MeSH concept]
Related MeSH Supplementary Concept(s)
- Cut2 protein, S pombe [MeSH Supplementary Concept]
- Irf2bpl protein, rat [MeSH Supplementary Concept]
- PDS1 protein, S cerevisiae [MeSH Supplementary Concept]
- PTTG1 protein, mouse [MeSH Supplementary Concept]
- pituitary tumor-transforming protein 1, human [MeSH Supplementary Concept]
- pituitary tumor-transforming protein 2, human [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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