DNA Replication Licensing Factor MCM3

Preferred Label : DNA Replication Licensing Factor MCM3;

NCIt synonyms : p102; DNA Polymerase Alpha Holoenzyme-Associated Protein P1; P1-MCM3; RLF Subunit Beta; Minichromosome Maintenance Protein 3; MCM3 Minichromosome Maintenance Deficient 3; P1 Protein; Minichromosome Maintenance Protein-3; Minichromosome Maintenance Deficient 3; hRlf Beta Subunit; Replication Licensing Factor, Beta Subunit; DNA Replication Factor MCM3;

NCIt definition : DNA replication licensing factor MCM3 (808aa, 91 kDa) is encoded by the human MCM3 gene. This protein is involved in the modulation of the cell cycle.;

NCIt note : This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and is acetylated by MCM3AP. The acetylation of the MCM3 protein inhibits the initiation of DNA replication and cell cycle progression. (Entrez Gene);

Details

Origin ID

C28684;

UMLS CUI

C0246743;

Automatic exact mappings (from CISMeF team)
- Minichromosome maintenance complex component 3 [OMIM gene]
- glycine dehydrogenase (decarboxylating) activity [GO term]
- minichromosome maintenance complex component 3 [MeSH Descriptor]
OMIM relation
- Minichromosome maintenance complex component 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MCM3 protein, human [MeSH concept]
- MCM3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- Licensing Factor Gene [NCIt concept]
- MCM3 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- MCM Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
gene_product_is_physical_part_of
- Pre-Replication Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Progression [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- DNA Replication [NCIt concept]
- Replication Initiation [NCIt concept]
- Replication Licensing [NCIt concept]

Keyword's position in hierarchy(ies) :

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