DNA Replication Licensing Factor MCM4

Preferred Label : DNA Replication Licensing Factor MCM4;

NCIt synonyms : P1-CDC21; CDC21; Cell Devision Cycle 21 Homolog; MCM4 Minichromosome Maintenance Protein 4; hCDC21; CDC54; CDC21 Homolog; MCM4; DNA Replication Licensing Factor-MCM4; EC 3.6.4.12;

NCIt definition : DNA replication licensing factor MCM4 (863 aa, 97 kDa) is encoded by the human MCM4 gene. This protein is involved in the initiation of DNA replication.;

NCIt note : A stable complex of MCM4, MCM6, and MCM7 associates with MCM2 specifically bound to histone H3. A key component of the pre-replication complex, hexameric MCM2-7 complex is likely involved in formation of replication forks and recruitment of replication factors. MCM2/4/6/7 complex possesses ATP-dependent DNA helicase activity and may initiate replication as a DNA unwinding enzyme. MCM4 phosphorylation by Cyclin/CDK1,2 suppresses helicase activity and chromatin binding, regulating replication. MCM4 is highly phosphorylated in mitotic cells;

Details

Origin ID

C33909;

UMLS CUI

C0663296;

Automatic exact mappings (from CISMeF team)
- Minichromosome maintenance complex component 4 [OMIM gene]
- minichromosome maintenance complex component 4 [MeSH Descriptor]
- minichromosome maintenance complex component 4 [HGNC gene]
- minichromosome maintenance complex component 4 [ORDO Gene]
OMIM relation
- Minichromosome maintenance complex component 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MCM4 protein, human [MeSH Supplementary Concept]
- MCM4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Helicase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Licensing Factor Gene [NCIt concept]
- MCM4 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- MCM Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Maintenance Process [NCIt concept]
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleic Acid Binding [NCIt concept]
- Replication Initiation [NCIt concept]
- Replication Licensing [NCIt concept]

Keyword's position in hierarchy(ies) :

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