Transcriptional Activator Protein Pur-Alpha

Preferred Label : Transcriptional Activator Protein Pur-Alpha;

NCIt synonyms : Purine-Rich Element Binding Protein A; PURA; Transcription Factor PUR1; Purine-Rich Single-Stranded DNA-Binding Protein Alpha; PUR Alpha; PUR Alpha Protein;

NCIt definition : Transcriptional activator protein Pur-alpha (322 aa, 35 kDa) is encoded by the human PURA gene. This protein is involved in the modulation of DNA replication.;

NCIt note : PURA protein is a potent transactivator able to bind purine-rich DNA sequences (GAGA boxes), often found upstream of gene transcription start sites. This protein is implicated in transcriptional control of many cellular genes, including MBP, FE65, and neuronal ACHR, as well as viral promoters for JCV and HIV-1 and is also involved in cell growth control and interacts with hypophosphorylated RB1. It interacts with large T-antigen and cellular protein YB-1 to activate JC viral DNA transcription. PURA is also a single-stranded DNA-binding protein with specific affinity for a (GGN)n element present in several eukaryotic DNA replication initiation zones.;

Details

Origin ID

C18977;

UMLS CUI

C0291181;

Automatic exact mappings (from CISMeF team)
- Pleomorphic undifferentiated sarcoma [ORDO Disease]
- Purine-rich element-binding protein a [OMIM gene]
- Pus [LOINC System]
- Pus (morphologic abnormality) [SNOMED CT concept]
- Pus (substance) [SNOMED CT concept]
- purine rich element binding protein A [ORDO Gene]
- pus [MeSH concept]
- pus [Radlex concept]
- pus, nos [SNOMED Notion]
- suppuration [MeSH Descriptor]
OMIM relation
- Purine-rich element-binding protein a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- PURA Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Replication Initiation [NCIt concept]
- Replication-Associated Process [NCIt concept]
- Transcriptional Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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