DNA Helicase MCM8

Preferred Label : DNA Helicase MCM8;

NCIt synonyms : EC 3.6.4.12; DNA Replication Licensing Factor MCM8; Minichromosome Maintenance 8; MCM8 Minichromosome Maintenance Deficient 8; Minichromosome Maintenance Protein 8; Minichromosome Maintenance Complex Component 8; MCM8;

NCIt definition : DNA helicase MCM8 (840 aa, 94 kDa) is encoded by the human MCM8 gene. This protein is involved in DNA repair.;

NCIt note : MCM8 and MCM9 are presumed to form a complex that acts as a hexameric helicase to maintain and repair DNA replication forks. (UniProt);

Details

Origin ID

C131553;

UMLS CUI

C1174540;

Automatic exact mappings (from CISMeF team)
- Minichromosome maintenance complex component 8 [OMIM gene]
- minichromosome maintenance complex component 8 [MeSH concept]
- minichromosome maintenance complex component 8 [MeSH Descriptor]
OMIM relation
- Minichromosome maintenance complex component 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MCM8 protein, human [MeSH Supplementary Concept]
- MCM8 protein, human [MeSH concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Helicase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- MCM8 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- MCM Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Maintenance Process [NCIt concept]
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]
- Gametogenesis [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleic Acid Binding [NCIt concept]
- Recombination Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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