EGFR-GRB2 Complex

Preferred Label : EGFR-GRB2 Complex;

NCIt synonyms : GRB2-EGFR Complex; EGFR:GRB2 Signaling Complex; EGFR:GRB2 Complex; GRB2:EGFR Complex; EGFR-GRB2 Signaling Complex;

NCIt definition : A protein complex comprised of two epidermal growth factor receptor (EGFR) family proteins, and one or two growth factor receptor-bound protein 2 (GRB2) adaptor proteins. These complexes form after epidermal growth factor (EGF) family ligands bind to EGFR proteins. Ligand binding triggers receptor dimerization and cross-receptor tyrosine phosphorylation, which allows the SH2 domains of each growth factor receptor-bound protein 2 to form a non-covalent bond with the phosphorylated EGFR proteins.;

Details

Origin ID

C116967;

UMLS CUI

C3891564;

Automatic exact mappings (from CISMeF team)
- Grb2-EGFR complex [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_plays_role_in_biological_process
- Receptor Signaling [NCIt concept]
has_gene_product_element
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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