Prexigebersen - CISMeF

Preferred Label : Prexigebersen;

NCIt synonyms : Liposomal Grb2 AS ODN;

NCIt related terms : Liposome-Incorporated Grb2 Antisense Oligodeoxynucleotide;

NCIt definition : A liposomal formulation containing the antisense oligodeoxynucleotide (ODN) growth factor receptor-bound protein 2 (Grb2), with potential antineoplastic activity. Upon administration, liposome-incorporated Grb2 antisense oligodeoxynucleotide binds directly to and blocks Grb2 mRNA, thereby preventing Grb2 protein synthesis, leading to inhibition of cell proliferation of cancer cells overexpressing Grb2. Grb2, an adaptor protein involved in growth signaling pathways, is upregulated in certain tumor cells.;

UNII : 8W1O4Y961B;

CAS number : 202484-91-1;

Molecule name : BP-100-1.01; BP-1001;

NCI Metathesaurus CUI : CL421657;

Details

Origin ID

C91736;

UMLS CUI

C2984524;

Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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