Preferred Label : Prexigebersen;
NCIt synonyms : Liposomal Grb2 AS ODN;
NCIt related terms : Liposome-Incorporated Grb2 Antisense Oligodeoxynucleotide;
NCIt definition : A liposomal formulation containing the antisense oligodeoxynucleotide (ODN) growth
factor receptor-bound protein 2 (Grb2), with potential antineoplastic activity. Upon
administration, liposome-incorporated Grb2 antisense oligodeoxynucleotide binds directly
to and blocks Grb2 mRNA, thereby preventing Grb2 protein synthesis, leading to inhibition
of cell proliferation of cancer cells overexpressing Grb2. Grb2, an adaptor protein
involved in growth signaling pathways, is upregulated in certain tumor cells.;
UNII : 8W1O4Y961B;
CAS number : 202484-91-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 202484-91-1
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G-SRS /a ;
Molecule name : BP-100-1.01; BP-1001;
NCI Metathesaurus CUI : CL421657;
Origin ID : C91736;
UMLS CUI : C2984524;
Semantic type(s)
- concept_is_in_subset
- has_target
