Preferred Label : Ivarmacitinib Sulfate;
NCIt synonyms : SHR 0302 Sulfate; SHR-0302 Sulfate; SHR0302 Sulfate;
NCIt definition : The sulfate salt form of ivarmacitinib, an orally available inhibitor of Janus-associated
kinase 1 (JAK1), with potential antineoplastic activity. Upon oral administration,
ivarmacitinib binds to and inhibits JAK1, thereby preventing JAK-dependent signaling.
This may lead to an inhibition of cellular proliferation in JAK1-overexpressing tumor
cells. The JAK-STAT (signal transducer and activator of transcription) signaling pathway
is a major mediator of cytokine activity and is often dysregulated in a variety of
tumor cell types. Additionally, JAK1 may be a primary driver of STAT3 phosphorylation
and signaling, which plays a role in neoplastic transformation, resistance to apoptosis,
tumor angiogenesis, metastasis, immune evasion, and treatment resistance.;
UNII : CN7B3Z5G04;
CAS number : 1639419-51-4;
NCI Metathesaurus CUI : CL1787939;
Origin ID : C186397;
UMLS CUI : C5565995;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
