Preferred Label : Ivarmacitinib;
NCIt synonyms : SHR-0302 Free Base; SHR0302 Free Base; SHR 0302 Free Base;
NCIt definition : An orally available inhibitor of Janus-associated kinase 1 (JAK1), with potential
antineoplastic activity. Upon oral administration, ivarmacitinib binds to and inhibits
JAK1, thereby preventing JAK-dependent signaling. This may lead to an inhibition of
cellular proliferation in JAK1-overexpressing tumor cells. The JAK-STAT (signal transducer
and activator of transcription) signaling pathway is a major mediator of cytokine
activity and is often dysregulated in a variety of tumor cell types. Additionally,
JAK1 may be a primary driver of STAT3 phosphorylation and signaling, which plays a
role in neoplastic transformation, resistance to apoptosis, tumor angiogenesis, metastasis,
immune evasion, and treatment resistance.;
UNII : K6K4B9Z5TV;
CAS number : 1445987-21-2;
NCI Metathesaurus CUI : CL1787142;
Origin ID : C186403;
UMLS CUI : C5565431;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
