Preferred Label : Tofacitinib Topical Cream;
NCIt synonyms : Tofacitinib Cream;
NCIt definition : A topical cream formulation containing the Janus kinase (JAK) inhibitor tofacitinib,
with potential immunomodulatory and anti-inflammatory activities. Upon topical administration,
tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers
and activators of transcription (STAT) signaling pathway. This may decrease the production
of pro-inflammatory cytokines, such as interleukin (IL)-6, -7, -15, -21, interferon-alpha
(IFN-a) and -beta (IFN-b), and may prevent both an inflammatory response and the inflammation-induced
damage caused by certain diseases. JAK are intracellular enzymes involved in signaling
pathways affecting hematopoiesis, immunity and inflammation.;
Origin ID : C212044;
concept_is_in_subset
- has_target
