Preferred Label : Ruxolitinib Phosphate Cream;
NCIt synonyms : INCB018424 Phosphate Cream;
NCIt definition : A topical cream formulation containing the phosphate salt form of ruxolitinib, a bioavailable
Janus-associated kinase (JAK) inhibitor, with potential immunomodulating activity.
Upon topical administration of the ruxolitinib phosphate cream, ruxolitinib specifically
binds to and inhibits the protein tyrosine kinases JAK 1 and 2; this inhibits signal
transduction pathways of various cytokines and reduces inflammation. The JAK-STAT
(signal transducer and activator of transcription) pathway plays a key role in the
signaling pathways initiated by many cytokines and growth factors; JAK kinases are
upregulated in various inflammatory and autoimmune diseases, including alopecia areata.;
NCI Metathesaurus CUI : CL508203;
Origin ID : C126791;
UMLS CUI : C4288268;
Semantic type(s)
- concept_is_in_subset
- has_target
