Preferred Label : JAK1 Inhibitor INCB052793;
NCIt definition : An orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1), with potential
antineoplastic activity. Upon oral administration, INCB052793 specifically binds to
and inhibits the phosphorylation of JAK1, which interferes with JAK-dependent signaling
and may lead to an inhibition of cellular proliferation in JAK1-overexpressing tumor
cells. The JAK-STAT (signal transducer and activator of transcription) signaling pathway
is a major mediator of cytokine activity and is often dysregulated in a variety of
tumor cell types.;
Molecule name : INCB052793;
Origin ID : C118629;
UMLS CUI : C3896740;
Semantic type(s)
- concept_is_in_subset
- has_target
