Preferred Label : Itacitinib;
NCIt synonyms : 3-Azetidineacetonitrile, 1-(1-((3-Fluoro-2-(trifluoromethyl)-4-pyridinyl)carbonyl)-4-piperidinyl)-3-(4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl)-;
NCIt definition : An orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential
antineoplastic and immunomodulating activities. Upon oral administration, itacitinib
selectively inhibits JAK-1, thereby inhibiting the phosphorylation of signal transducer
and activator of transcription (STAT) proteins and the production of proinflammatory
factors induced by other cytokines, including interleukin-23 (IL-23) and interleukin-6
(IL-6). The JAK-STAT pathway plays a key role in the signaling of many cytokines and
growth factors and is involved in cellular proliferation, growth, hematopoiesis, and
the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative
disorders, and various malignancies.;
UNII : 19J3781LPM;
InChIKey : KTBSXLIQKWEBRB-UHFFFAOYSA-N;
CAS number : 1334298-90-6;
Molecule name : INCB 039110; INCB-039110;
Origin ID : C116855;
UMLS CUI : C4519324;
Currated CISMeF NLP mapping
- Manual BTNT mappings - CISMeF
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
