NCIt definition : The adipate salt form of itacitinib, an orally bioavailable inhibitor of Janus-associated
kinase 1 (JAK1) with potential antineoplastic and immunomodulating activities. Upon
oral administration, itacitinib selectively inhibits JAK-1, thereby inhibiting the
phosphorylation of signal transducer and activator of transcription (STAT) proteins
and the production of proinflammatory factors induced by other cytokines, including
interleukin-23 (IL-23) and interleukin-6 (IL-6). The JAK-STAT pathway plays a key
role in the signaling of many cytokines and growth factors and is involved in cellular
proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be
upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.;
UNII : XZG407XE0Y;
InChIKey : CEGWJIQFBNFMHQ-UHFFFAOYSA-N;
CAS number : 1334302-63-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1334302-63-4
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Semantic type(s)