NCIt definition : The adipate salt form of itacitinib, an orally bioavailable inhibitor of Janus-associated
kinase 1 (JAK1) with potential antineoplastic and immunomodulating activities. Upon
oral administration, itacitinib selectively inhibits JAK-1, thereby inhibiting the
phosphorylation of signal transducer and activator of transcription (STAT) proteins
and the production of proinflammatory factors induced by other cytokines, including
interleukin-23 (IL-23) and interleukin-6 (IL-6). The JAK-STAT pathway plays a key
role in the signaling of many cytokines and growth factors and is involved in cellular
proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be
upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.;
Semantic type(s)