Preferred Label : Janus kinase 1;
Definition : JAK1 is a human tyrosine kinase protein essential for signaling for certain type I
and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine
receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R
and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor
family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary
neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R).
It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ)
interferons, and members of the IL-10 family via type II cytokine receptors. Jak1
plays a critical role in initiating responses to multiple major cytokine receptor
families. (Wikipedia);
Synonyme : JAK1;
Origin ID : VBHG595P-9;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
JAK1 is a human tyrosine kinase protein essential for signaling for certain type I
and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine
receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R
and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor
family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary
neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R).
It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ)
interferons, and members of the IL-10 family via type II cytokine receptors. Jak1
plays a critical role in initiating responses to multiple major cytokine receptor
families. (Wikipedia)
