Ruxolitinib - CISMeF

Preferred Label : Ruxolitinib;

NCIt synonyms : Oral JAK Inhibitor INCB18424; (3R)-3-cyclopentyl-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)pyrazol-1-yl)propanenitrile;

NCIt definition : An orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.;

UNII : 82S8X8XX8H;

InChIKey : HFNKQEVNSGCOJV-OAHLLOKOSA-N;

CAS number : 941678-49-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 941678-49-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : INCB-18424;

Chemical formula : C17H18N6;

Codes from synonyms : 455;

Details

Origin ID

C77888;

UMLS CUI

C2931926;

Automatic exact mappings (from CISMeF team)
- Ruxolitinib [ICD-11 Extension code]
- ruxolitinib [ATC Code]
Currated CISMeF NLP mapping
- Ruxolitinib (substance) [SNOMED CT concept]
- ruxolitinib [MeSH concept]
- ruxolitinib [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing ruxolitinib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing ruxolitinib (medicinal product) [SNOMED CT concept]
- Ruxolitinib (substance) [SNOMED CT concept]
- ruxolitinib [MeSH concept]
- ruxolitinib [ATC Code]
- ruxolitinib [MeSH Supplementary Concept]
- ruxolitinib [ATC Code]
Validated automatic mappings to BTNT
- ruxolitinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Ruxolitinib Phosphate [NCIt concept]
has_target
- Tyrosine-Protein Kinase JAK1 [NCIt concept]
- Tyrosine-Protein Kinase JAK2 [NCIt concept]
is_free_acid_or_base_form_of
- Ruxolitinib Phosphate [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients