" /> Ruxolitinib - CISMeF





Preferred Label : Ruxolitinib;

NCIt synonyms : Oral JAK Inhibitor INCB18424; (3R)-3-cyclopentyl-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)pyrazol-1-yl)propanenitrile;

NCIt definition : An orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.;

UNII : 82S8X8XX8H;

InChIKey : HFNKQEVNSGCOJV-OAHLLOKOSA-N;

CAS number : 941678-49-5;

Molecule name : INCB-18424; INCB 018424; INCB-018424;

Chemical formula : C17H18N6;

Codes from synonyms : 455;

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30/05/2025


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