Preferred Label : Basiliximab-IR700 RM-1995;
NCIt synonyms : Basiliximab-IRDye700DX;
NCIt definition : An antibody-dye conjugate composed of basiliximab, a chimeric monoclonal antibody
directed against the alpha subunit of interleukin-2 receptor (IL-2R alpha, CD25 or
Tac antigen), and conjugated to the light-activatable phthalocyanine dye IR700 (IRDye
700DX), with potential antineoplastic activity. Upon intravenous administration of
basiliximab-IR700 RM-1995, the basiliximab moiety targets and binds to IL-2R alpha
expressed on the surface of activated regulatory T-lymphocytes (Tregs) in the tumor
microenvironment (TME). Upon binding and localized application of 690nm nonthermal
red light using the PIT690 laser system, the IR700 dye transiently becomes activated,
disrupts the cell membrane and selectively kills the IL-2R alpha-expressing Tregs.
This may abrogate the Tregs-mediated immunosuppressive nature of the TME and may result
in systemic anti-cancer immune activation. This may activate a cytotoxic T-lymphocytes
(CTL)-mediated immune response against tumor cells. CD25-positive Tregs inhibit antitumor
immune responses and enhance tumor growth.;
Molecule name : RM 1995; RM-1995;
NCI Metathesaurus CUI : CL1779119;
Origin ID : C186725;
UMLS CUI : C5667084;
Semantic type(s)
- concept_is_in_subset
- has_target
