Preferred Label : Anti-CD25 Monoclonal Antibody BA1106;
NCIt definition : A human monoclonal antibody directed against CD25 (interleukin-2 receptor subunit
alpha; IL-2R alpha; IL-2Ra), with potential antineoplastic activity. Upon administration,
anti-CD25 monoclonal antibody BA1106 targets and binds to CD25 expressed on tumor-infiltrating
regulatory T (Treg) cells. This may deplete Treg cells in the tumor microenvironment
(TME) through antibody-dependent cellular cytotoxicity (ADCC) and prevent immunosuppression,
thereby increasing the number of effector T (Teff) cells and enhancing anti-tumor
immune responses. CD25, the alpha chain of the IL-2 receptor, is highly expressed
on Treg cells but not on Teff cells in tumors.;
Molecule name : BA-1106; BA 1106;
NCI Metathesaurus CUI : CL1906423;
Origin ID : C198991;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
