" /> LMB-2 Immunotoxin - CISMeF





Preferred Label : LMB-2 Immunotoxin;

NCIt synonyms : Humanized AntiTac Toxin; Immunotoxin LMB-2; Anti-Tac(Fv)-PE38; LMB-2 (Anti-TAC(FV)-PE-38); LMB-2;

NCIt definition : A fusion protein consisting of the Fv portion of a monoclonal antibody attached to a 38-kDa fragment of the Pseudomonas exotoxin A (with amino acids 365-380 deleted). LMB-2 immunotoxin targets the interleukin 2 receptor (also known as IL-2R or CD25) which is expressed on activated normal T and B cells and macrophages and on the cells of various hematologic malignancies. The antibody attaches to the IL-2R on the cell membrane, facilitating the entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04);

Alternative definition : NCI-GLOSS: A toxic substance linked to an antibody that attaches to tumor cells and kills them.;

NSC code : 676422;

Codes from synonyms : CDR0000046198;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
01/06/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.