Vopikitug - CISMeF

Preferred Label : Vopikitug;

NCIt synonyms : Anti-CD25 Monoclonal Antibody RG6292; T-regulatory Cell-depleting Antibody RO7296682; Anti-CD25 Monoclonal Antibody RO7296682;

NCIt definition : A monoclonal antibody against CD25 (IL-2R alpha), with potential antineoplastic activity. Upon administration, vopikitug targets and binds to CD25 expressed on tumor-infiltrating regulatory T (Treg) cells. This may deplete Treg cells and prevent immunosuppression, thereby enhancing anti-tumor immune responses. CD25, the alpha chain of the interleukin (IL)-2 receptor, is highly expressed on Treg cells but not on effector T (Teff) cells in tumors.;

UNII : HV8TQI2IKP;

CAS number : 2733581-99-0;

Molecule name : RG 6292; RO 7296682; RG-6292; RO-7296682;

NCI Metathesaurus CUI : CL1407855;

Details

Origin ID

C173969;

UMLS CUI

C5418045;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Interleukin-2 Receptor Subunit Alpha [NCIt concept]

Keyword's position in hierarchy(ies) :

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