NCIt definition : A monoclonal antibody against CD25 (IL-2R alpha), with potential antineoplastic activity.
Upon administration, vopikitug targets and binds to CD25 expressed on tumor-infiltrating
regulatory T (Treg) cells. This may deplete Treg cells and prevent immunosuppression,
thereby enhancing anti-tumor immune responses. CD25, the alpha chain of the interleukin
(IL)-2 receptor, is highly expressed on Treg cells but not on effector T (Teff) cells
in tumors.;
UNII : HV8TQI2IKP;
CAS number : 2733581-99-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2733581-99-0
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G-SRS /a ;
Molecule name : RG 6292; RO 7296682; RG-6292; RO-7296682;
Semantic type(s)