Preferred Label : Yttrium Y 90 Basiliximab;
NCIt synonyms : 90Y Basiliximab; Yttrium Y 90-DOTA-Basiliximab;
NCIt definition : A radioimmunoconjugate composed of basiliximab, a chimeric, mouse-human monoclonal
antibody directed against the alpha subunit of interleukin-2 receptor (IL-2R alpha,
CD25 or Tac antigen), and labeled with yttrium y 90, with potential antineoplastic
activity. The basiliximab moiety of yttrium Y 90 basiliximab selectively binds to
IL-2R alpha expressed on the surface of activated T-lymphocytes, thereby preventing
IL-2 binding and blocking the IL-2-mediated activation of lymphocytes. The yttrium
y 90 moiety selectively delivers a cytotoxic dose of beta radiation to lymphocytes
that express the IL-2 receptor. This may prevent T cell-mediated activation of the
immune system against a certain transplant and may prevent transplant rejection.;
NCI Metathesaurus CUI : CL433016;
Origin ID : C99167;
UMLS CUI : C3274580;
Semantic type(s)
- concept_is_in_subset
- has_target
