" /> Feladilimab - CISMeF





Preferred Label : Feladilimab;

NCIt synonyms : Anti-ICOS Agonist Antibody GSK3359609;

NCIt definition : An agonistic antibody for the inducible T-cell co-stimulator (ICOS; CD278), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, feladilimab targets and binds to ICOS expressed on tumor infiltrating CD4-positive T-cells. This stimulates ICOS-positive T-cell proliferation, enhances cytotoxic T-lymphocyte (CTL) survival and increases CTL-mediated immune responses against tumor cells. ICOS, a T-cell specific, CD28-superfamily costimulatory molecule and immune checkpoint protein, is normally expressed on certain activated T-cells and plays a key role in the proliferation and activation of T-cells.;

UNII : OUP4QB2A3R;

CAS number : 2252518-85-5;

Molecule name : GSK3359609;

NCI Metathesaurus CUI : CL507897;

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10/05/2025


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