" /> Feladilimab - CISMeF





Preferred Label : Feladilimab;

NCIt synonyms : Anti-ICOS Agonist Antibody GSK3359609;

NCIt definition : An agonistic antibody for the inducible T-cell co-stimulator (ICOS; CD278), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, feladilimab targets and binds to ICOS expressed on tumor infiltrating CD4-positive T-cells. This stimulates ICOS-positive T-cell proliferation, enhances cytotoxic T-lymphocyte (CTL) survival and increases CTL-mediated immune responses against tumor cells. ICOS, a T-cell specific, CD28-superfamily costimulatory molecule and immune checkpoint protein, is normally expressed on certain activated T-cells and plays a key role in the proliferation and activation of T-cells.;

UNII : OUP4QB2A3R;

CAS number : 2252518-85-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2252518-85-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : GSK3359609;

NCI Metathesaurus CUI : CL507897;

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15/05/2024


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