Preferred Label : NEO1 wt Allele;
NCIt synonyms : IGDCC2; Neogenin 1 wt Allele; NGN; Neogenin Homolog 1 (Chicken) Gene; HsT17534;
NCIt definition : Human NEO1 wild-type allele is located within 15q22.3-q23 and is approximately 253
kb in length. This allele, which encodes neogenin, plays a role in cell cycle modulation.;
NCIt note : Homolog of the chicken gene neogenin, which is induced in neural cells immediately
before cell cycle withdrawal and terminal differentiation. The gene is infrequently
affected by alterations in cancer and no alterations in expression were observed in
more than 50 cancers studied, including glioblastoma, medulloblastoma, neuroblastoma,
colorectal, breast, cervical, and pancreatic cancer cell lines, and xenografts. Neogenin
may play a role in mammary carcinogenesis as well as morphogenesis and neogenin and
restin have roles in proproliferation/survival action on ovarian cancer cells.;
GenBank Accession Number : NM_002499;
Origin ID : C52345;
UMLS CUI : C1705034;
OMIM relation
- Semantic type(s)
- gene_found_in_organism
- gene_in_chromosomal_location
- gene_is_element_in_pathway
- gene_plays_role_in_process
