" /> B-Cell Receptor CD22 - CISMeF





Preferred Label : B-Cell Receptor CD22;

NCIt synonyms : CD22 Antigen; Lyb8; B-Cell Antigen CD22; B-Lymphocyte Cell Adhesion Molecule; Sialic Acid-Binding Immunoglobulin-Like Lectin 2; Siglec-2; T-Cell Surface Antigen Leu-14; Sialic Acid-Binding Ig-Like Lectin 2; BL-CAM;

NCIt related terms : CD22;

NCIt definition : B-cell receptor CD22 (847 aa, 95 kDa) is encoded by the human CD22 gene. This protein is involved in B-cell/B-cell interactions and downstream signaling.;

NCIt note : The CD22 gene is expressed in pro-B cells as a cytoplasmic protein and later as a cell surface protein, persisting until they differentiate into plasma cells. CD22 antigen is a glycoprotein heterodimer with two subunits from separate precursor molecules that arise by differential RNA processing of the same gene. The larger subunit is composed of an extracellular portion of seven Ig domains and a smaller subunit of five Ig domains. Structurally related to MAG, NCAM, and CEA, CD22 participates in adhesion between B-cells and other cell types. Conserved ITIM motifs in inhibitory receptors are sites for phosphorylation by a SRC kinase and dephosphorylation by tyrosine phosphatase SHP1 or inositol phosphatase SHIP, transducing signals to distinct pathways. CD22 ITIMs interact with SHP1 and oppose activation mediated by the B-cell receptor. CD22 is a negative regulator of antigen receptor signaling.;

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15/05/2024


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