Inotuzumab Ozogamicin

Preferred Label : Inotuzumab Ozogamicin;

NCIt synonyms : Anti-CD22-CalichDMH Conjugate;

NCIt definition : A CD22-targeted cytotoxic immunoconjugate composed of a humanized IgG4 anti-CD22 antibody covalently linked to N-acetyl-gamma-calicheamicin dimethyl hydrazide (CalichDMH) with potential antineoplastic activity. Inotuzumab ozogamicin is rapidly internalized upon binding of the antibody moiety to B cell-specific CD22 receptors, delivering the conjugated CalichDMH intracellularly; the CalichDMH moiety binds to the minor groove of DNA in a sequence-specific manner, resulting in double-strand DNA breaks and apoptosis. CalichDMH is a derivative of gamma calicheamicin, a cytotoxic antibiotic produced by the bacterium Micromonospora echinospora.;

UNII : P93RUU11P7;

CAS number : 635715-01-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 635715-01-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Besponsa;

Molecule name : CMC-544; WAY-207294; Way 207294;

Chemical formula : C73H96IN6O25S3;

Codes from synonyms : 273;

Details

Origin ID

C71542;

UMLS CUI

C1567130;

Automatic exact mappings (from CISMeF team)
- Inotuzumab ozogamicin [ICD-11 Extension code]
See also inter- (CISMeF)
- Besponsa [MeSH concept]
- Product containing inotuzumab ozogamicin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Inotuzumab Ozogamicin [MeSH Descriptor]
- Inotuzumab Ozogamicin [MeSH concept]
- Inotuzumab ozogamicin (substance) [SNOMED CT concept]
- Product containing inotuzumab ozogamicin (medicinal product) [SNOMED CT concept]
- inotuzumab ozogamicin [ATC Code]
Validated automatic mappings to BTNT
- inotuzumab ozogamicin [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Cell Receptor CD22 [NCIt concept]
is_component_of_chemotherapy_regimen
- Inotuzumab Ozogamicin Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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