" /> Moxetumomab Pasudotox - CISMeF





Preferred Label : Moxetumomab Pasudotox;

NCIt synonyms : Immunotoxin CAT-8015; Moxetumomab Pasudotox-TDFK;

NCIt related terms : CAT-8015; anti-CD22 immunotoxin CAT-8015;

NCIt definition : A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody covalently fused to a 38 KDa fragment of Pseudomonas exotoxin-A (PE38) with potential antineoplastic activity. The Fv portion of anti-CD22 immunotoxin CAT-8015 binds to CD22, a cell surface receptor expressed on a variety of malignant B-cells, thereby delivering the toxin moiety PE38 directly to tumor cells. Once internalized, PE38 induces caspase-mediated apoptosis via a mechanism involving mitochondrial damage and blocks translational elongation by binding to elongation factor 2 (EF-2). Anti-CD22 immunotoxin CAT-8015 exhibits a greater affinity for CD22 than its predecessor, anti-CD22 immunotoxin CAT-3888 (BL22 immunotoxin), and hence may be more effective against tumor cells expressing lower levels of CD22.;

Alternative definition : NCI-GLOSS: A monoclonal antibody linked to a toxic substance. It is being studied in the treatment of some types of B-cell cancer. Anti-CD22 immunotoxin CAT-8015 is made in the laboratory. It binds to CD22, a protein on the surface of normal B cells and B-cell tumors, and kills the cells.;

UNII : 2NDX4B6N8F;

CAS number : 1020748-57-5;

Drug name : Lumoxiti;

Molecule name : GCR-8015; CAT-8015; HA22; CAT 8015;

Codes from synonyms : CDR0000562550; CDR0000543126; 342;

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01/06/2025


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