Preferred Label : Pinatuzumab Vedotin;
NCIt synonyms : Antibody-Drug Conjugate DCDT2980S; ADC DCDT2980S;
NCIt definition : An antibody-drug conjugate (ADC) composed of MCDT2219A, a humanized IgG1 anti-CD22
monoclonal antibody covalently linked, via a protease-cleavable peptide linker, to
monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule
disrupting agent, with potential antineoplastic activity. Upon administration, the
monoclonal antibody moiety of pinatuzumab vedotin binds to B cell-specific CD22 receptors
and is rapidly internalized, thereby delivering MMAE intracellularly. Upon proteolytic
cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M
phase arrest and tumor cell apoptosis. CD22, a cell surface glycoprotein, is expressed
on mature B-cells and on most malignant B-cells.;
UNII : 6KA1906BLC;
CAS number : 1313706-14-7;
Molecule name : DCDT2980S;
Origin ID : C104167;
UMLS CUI : C4078700;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
