Preferred Label : Anti-CD19/CD20/CD22/CD30 CAR-T Cells;
NCIt synonyms : Anti-CD19/CD20/CD22/CD30 Chimeric Antigen Receptor-T Cells; CAR-T CD19/CD20/CD22/CD30;
NCIt definition : A preparation of human T-lymphocytes engineered to express a chimeric antigen receptor
(CAR) specific for the tumor-associated antigens (TAAs) cluster of differentiation
19 (CD19), CD20, CD22 and CD30, with potential immunostimulating and antineoplastic
activities. Upon administration, the anti-CD19/CD20/CD22/CD30 CAR-T cells target and
bind to CD19, CD20, CD22 and CD30 expressed on the surface of certain tumor cells.
This induces selective toxicity in tumor cells expressing these TAAs. The TAAs are
overexpressed in certain hematologic malignancies.;
NCI Metathesaurus CUI : CL553274;
Origin ID : C151935;
UMLS CUI : C4726562;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
