NCIt definition : Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding
a chimeric antigen receptor (CAR) consisting of an anti-CD22 human single chain variable
fragment (scFv) and linked to the co-stimulatory domain 4-1BB (CD137) coupled to the
zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and
antineoplastic activities. Upon reintroduction into the patient, the autologous anti-CD22
CAR-4-1BB-TCRz -transduced T-lymphocytes CART22-65s express anti-CD22-CAR on their
cell surfaces and bind to the CD22 antigen on tumor cell surfaces, resulting in lysis
of CD22-expressing tumor cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein,
is expressed on malignant B-cells.;