NCIt definition : A hinge-stabilized human immunoglobulin G4 (IgG4) bispecific antibody directed against
both the tumor-associated antigen (TAA) CD22 and the co-stimulatory T-cell-specific
surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities.
Upon administration, anti-CD22/anti-CD28 bispecific antibody REGN5837 targets and
binds to both CD28 expressed on T-cells and CD22 expressed on tumor cells, which crosslinks
the T-cells to the tumor cells. This may result in the activation of a cytotoxic T-lymphocyte
(CTL) response against the CD22-expressing tumor cells. CD22 is exclusively expressed
on B-cells and is often overexpressed in B-lymphocytic malignancies. It negatively
regulates the B-cell receptor.;
Semantic type(s)