Preferred Label : Allogeneic CD22-specific Universal CAR-expressing T-lymphocytes UCART22;
NCIt synonyms : Allogenic Engineered T-cells Expressing Anti- CD22 CAR UCART22; Allogeneic Gene-edited CAR T-Cells UCART22; UCART22 Cells; Allogeneic TALEN Gene-edited CAR T-Cells UCART22;
NCIt definition : A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like
effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified
to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen
(TAA) human CD22 with potential immunomodulating and antineoplastic activities. Upon
transfusion, allogeneic CD22-specific universal CAR-expressing T-lymphocytes UCART22
express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor
cell surfaces, resulting in lysis of CD22-expressing tumor cells. CD22, a cell surface
glycoprotein, is expressed on mature B-cells and on most malignant B-cells.;
Molecule name : UCART 22; UCART-22;
NCI Metathesaurus CUI : CL978908;
Origin ID : C165696;
UMLS CUI : C5237380;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
